Does fat cause diabetes? — Disclaimer: We all have a bias in this debate. Sometimes I agree more with the low-carb crowd, but other times I can’t stand the low-carb dogma. I can’t be perfect in this analysis, but I will at least explain my rationale. This topic doesn’t need a long introduction. The big…

Gee, has it been a long time since I was able to write on Medium. I’ve been swamped with lots of stuff that I will hopefully be able to post on here eventually. …

How we’ve bastardized our understanding of the physiology of lipids for the sake of simplicity — The study and understanding of dietary fatty acids in human health and disease is of undeniable importance. Fats provide humans with a crucial form of energy and mode of transporting numerous nutrients through the body, rendering fats an essential nutrient — we need to eat them to survive. The conventional…

Ketone bodies and their use as a metabolite for the brain and neurons is probably the most-studied aspect of ketone physiology. It’s well known and established that ketones have an important role in the treatment of a few neurological conditions. That also makes compelling interest to explore other medical conditions…

Sorry it’s been a while, y’all. I had a pretty major move and other life things happen. Hopefully things clear up again. So, I have a question to start off this post. What is the most significant risk factor for chronic disease (cancer, diabetes, neurodegerative disease, cardiovascular disease, etc.), …

A few days ago I discussed some important energy-sensing pathways in biological systems that can play major roles in the development of human diseases. I was told by a friend that I should follow that post up with another post on how to activate those pathways. Really, the best way…

One of the things I personally find fascinating about all life forms is the universal ability to sense cellular energy status. All biological systems have multiple ways of detecting low levels of cellular energy-containing molecules (e.g. ATP, NADH, etc.) and downstream feedback mechanisms to increase the production of energy-producing molecules…

Sorry it’s been a while, guys. Life has had me pinned down pretty bad lately. Hopefully I’ll be able to get back on track. So, berberine, Metformin, and AMPK. Berberine is a pretty interesting supplement. It’s been used for thousands of years in traditional Chinese medicine, and can be a…

The general model that people use when people talk about entering ketosis is this: Carb restrict→ ↓glucose→ ↓insulin:glucagon ratio→ ↓glycogen→ ↑ketones Or, to be put in another way: People have stated time and time again that in order to a state of ketosis, glycogen stores need to be depleted. It’s…